Objective: To investigate the performance of the body fluid application on the Sysmex XE-5000.

Methods: The XE-5000 accuracy, precision, and analytic measurement range, as well as correlation with standard methods were evaluated using serous, synovial, and cerebrospinal fluids (CSFs).

Results: The body fluid application on the XE-5000 showed good precision and correlation with previous methods for nucleated cell counts and RBC counts.

Conclusion: Evaluation of the body fluid application on the Sysmex XE-5000 showed significant improvement in the ability of automated hematology analyzers regarding body fluid analysis.