TcR
TcR The specific receptor for antigen on T lymphocytes, the TcR (), is a heterodimeric protein with motifs that are similar to immuno…
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Generation of Antibody Diversity
Antibody diversity is generated by the following mechanisms. Immunoglobulin Gene Rearrangements 1) The joining of various V, D and J genes is …
Immunoglobulin Supergene Family
The immunoglobulin supergene family is a group of structurally similar glycoproteins, which mediate antigen recognition and cellular …
Cells of the Immune System
Myeloid Cells Neutrophils Neutrophils are the first circulating phagocytic cells recruited to the site of infection and inf…
Molecular Communications in the Immune System
Cells of the immune system have profound immunoregulatory influences on each other. This regulation is mediated in large part by pote…
Reticuloendothelial System (RES)
The second major cellular system, the RES, ( Fig. 1-1 ) harbors macrophages, which are cells that play major roles in 1) …
Lymphoid System
The lymphoid system consists of organs that house 1) T and B cells that are responsible for antigen-specific immunity and 2) NK c…