The Complement System
The Complement System The complement system consists of a group of glycoproteins in the extracellular space that can be stimulated in…
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Recognition of Self and Immune Tolerance
Self Tolerance The immune system has evolved to distinguish between self and non-self antigens and to largely el…
Major Histocompatibility Complex (MHC)
General Features These molecules play a very important role in the recognition of self and non-self antigens by T…
CD3 Complex
CD3 Complex The TcR cannot bind to soluble antigens but they recognize antigenic peptides bound to MHC molecules (i.e. class I or cla…
TcR α/β
TcR α/β Most T cells express the α/β type of TcR. The genomic organization of the α and β genes is more complicated than that of the …
TcR
TcR The specific receptor for antigen on T lymphocytes, the TcR (), is a heterodimeric protein with motifs that are similar to immuno…
Generation of Antibody Diversity
Antibody diversity is generated by the following mechanisms. Immunoglobulin Gene Rearrangements 1) The joining of various V, D and J genes is …