Persistent Generalized Lymphadenopathy (PGL)

There is loss of normal lymph node architecture as the immune system fails with emergence from latency of HIV infection. It is marked by development of generalized lymphadenopathy. This condition, described by the term persistent generalized lymphadenopathy (PGL), is not life-threatening. Lymph nodes throughout the body are large but usually do not exceed 3 cm in size and they may vary in size over time.